May 182024
 

Yesterday, Wonkette informed me about the male-genitals-shaped balloons Trump** supporters had released Thursday outside the courthouse where he is being tried. Most of us outgrow our toddler obsession with genitals at an age much younger than these people have (God knows how) achieved. Also, there was a kerfuffle in the House involving Representatives Jasmine Crockett and Marjorie Three Names. Many people have had something to say about this. My take is that I’m going to the Atlanta Black Star to get some Black folks’ take before I even begin to formulate my lily-white take.  And then, there’s this.  (And no, you aren’t losig it, Jamie is still from Maryland -that was in error.)

This story from Joyce Vance is years old – but she (and the nation) have only just learned about it now. And that fact alone may be the biggest part of the story.

Sigh. I suppose we should have known this was coming – somewhere. And it will probably be repeated. It is well sourced, but I chose this link rather than ne of the sources, partly because I thought there was value in the comments.

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May 172024
 

Yesterday, although there’s more been published about it now, I decided to use this, the first I heard of it, to share. And the cherry on the sundae is that yes, Maggie was in court that day (as a “journalist”) so, whether intentionally or not, it was said to her face.

This from Heather Cox Richardson combines encouraging news about the actual state of our economy with discouraging news about what most people think about the economy, and points up the importance of not only what the media report, but also how they report on it.

Interesting idea. It certainly could be a lot of fun. Has anyone told Pete Buttigieg about this? (apparently someone has, since the article says they have to abide by Federal Railroad rules.)

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May 132024
 

Yesterday, I saw another Parody Project production. I’m not sure it’s new, but it is delightful. (The original song is IMO deplorable, but this may redeem it.) Also, Trinette was by (and returns greetings). I had a whole bunch of stuff- trash, recyclables, and charity – which I needed help getting it out. After seeing Virgil, despite coming home exhausted, I had a burst of energy over the week. That helped me with the decision to start making it every other week to see him.

Just in case you needed, or someone you knw needs, yet another reason to do every possible thing to prevent Trump** from returning to the White House

This site was down yesterday evening, but should be up today .  (And I don’t want to hear a single word about a PhD candidate using a double negative. There’s more to brains than formal grammar.)

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Apr 062024
 

When I saw this article (and particularly when I learned something else I’ll get to after the article). I figured I had to go right to the top – Athena, the goddess of wisdom. Athena is likely so intellectual because she wasn’t born as we understand it – she emerged fully formed and an adult from Zeus’s head (I assume without the helmet, although the size of the helmet does suggest a large brain.)

At a time when we are aware that Alzheimer’s disease exists, and that there is no cure, many of us are terrified of it – of having it ourselves, and of it happening to someone near and dear. I know my mother was terrified of it. (She was spared it – she was still expertly solving crossword puzzles until her final coma, caused by pneumonia, at age 93.) So I can’t imagine anyone willing to miss out on any opportunity to avoid it, or to slow its progress.
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New studies suggest millions with mild cognitive impairment go undiagnosed, often until it’s too late

Mild cognitive impairment can be an early sign of Alzheimer’s disease or other dementias.
ivanastar/iStock via Getty Images Plus

Soeren Mattke, University of Southern California and Ying Liu, USC Dornsife College of Letters, Arts and Sciences

Mild cognitive impairment – an early stage of dementia – is widely underdiagnosed in people 65 and older. That is the key takeaway of two recent studies from our team.

In the first study, we used Medicare data for about 40 million beneficiaries age 65 and older from 2015 to 2019 to estimate the prevalence of mild cognitive impairment in that population and to identify what proportion of them had actually been diagnosed.

Our finding was sobering: A mere 8% of the number of cases with mild cognitive impairment that we expected based on a statistical model had actually been diagnosed. Scaled up to the general population 65 and older, this means that approximately 7.4 million cases across the country remain undiagnosed.

In the second study, we analyzed data for 226,756 primary care clinicians and found that over 99% of them underdiagnosed mild cognitive impairment in this population.

Why it matters

Mild cognitive impairment is an early symptom of Alzheimer’s disease in about half of cases and progresses to dementia at a rate of 10% to 15% per year. It includes symptoms such as losing the ability to remember recent events and appointments, make sound decisions and master complex tasks. Failure to detect it might deprive patients of an opportunity to get treated and to slow down disease progression.

Mild cognitive impairment can sometimes be caused by easily addressable factors, such as medication side effects, thyroid dysfunction or vitamin B12 deficiency. Since mild cognitive impairment has the same risk factors as cardiovascular disease, such as high blood pressure and cholesterol, medication management of these risks combined with diet and exercise can reduce the risk of progression.

In 2023, the Food and Drug Administration approved the drug lecanemab as the first disease-modifying treatment for Alzheimer’s disease, the most common cause of mild cognitive impairment. In contrast to previous drugs, which can temporarily improve symptoms of the disease, such as memory loss and agitation, this new treatment addresses the underlying cause of the disease.

Lecanemab, a monoclonal antibody, reduces amyloid plaques in the brain, which are toxic protein clumps that are believed to contribute to the progression of the disease. In a large clinical trial, lecanemab was able to reduce the progression of early-stage Alzheimer’s disease. A similar drug, donanemab, also succeeded in a clinical trial and is expected to be approved sometime in 2024.

However, these drugs must be used in the early stages of Alzheimer’s disease, ideally when a patient has only mild cognitive impairment, as there is no evidence that they are effective in advanced stages.

An earlier diagnosis leads to early treatment and better outcomes.

What still isn’t known

Many factors contribute to the lack of timely detection. But researchers don’t have a good understanding of the relative importance of those individual factors or how to reduce the high rate of underdiagnosis.

While distinct, symptoms are subtle and their slow progression means that they can be overlooked or misinterpreted as normal aging. A neurologist in China told our research team that diagnosis rates spike in China after the New Year’s holiday, when children who haven’t seen their parents for a year notice changes that are harder to pick up when interacting with someone daily.

Doctors also commonly discount memory concerns as normal aging and doubt that much can be done about it. While cognitive tests to distinguish mild cognitive impairment from pathologic decline do exist, they take about 15 minutes, which can be hard to come by during the limited time of a doctor’s visit and may require a follow-up appointment.

What’s next

People, particularly those in their 60s and beyond, as well as their families and friends need to be vigilant about cognitive decline, bring it up during doctor’s appointments and insist on a formal assessment.

The Medicare yearly “wellness” visit is an opportunity to explore such concerns, but only about half of beneficiaries take advantage of it.

Just as physicians ask patients about unexplained weight loss and take those concerns seriously, we believe questions that explore a patient’s cognitive state need to become the norm.

The Research Brief is a short take on interesting academic work.The Conversation

Soeren Mattke, Director of the USC Dornsife Brain Health Observatory, University of Southern California and Ying Liu, Research Scientist, Center for Economic and Social Research, USC Dornsife College of Letters, Arts and Sciences

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Pat B, (who is celebrating her fiftieth wedding anniversary today) has graciously given me permission to share that this coming Friday she has an appointment with her Doctor to discuss her memory loss. While no one can prove it, I would not be surprised to learn this was inspired by Athena. I can’t imagine anything wiser than getting checked out for any possible signs of dementia, knowing that waiting will not make it any better but it could make it worse. Thank you, Athena, and may you inspire all of us who are 65 or older to be wise also.

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Mar 132024
 

Yesterday, I got a new email from the Theater of War and immediately thought of SpyCat, because they will be doing two readings of “An Enemy of the People” live in Ohio in April, in Mount Vernon and Gambier on the 6th and 7th respectively (and of course also on Zoom.) These productions are not just theater – there’s no stage, no sets, no costumes or makeup, just readings, and voice acting. And the whole play is never presented – selections are read pertinent to the public health topic addressed. And after the reading, audience members react, both on site and now, since the pandemic, through Zoom, and share through their experience what has touched them and what applies to today. Their website is theaterofwar.com, and it’s headed up with a four minute video describing what they do and why, with three examples (obviously very short.) But there’s also a lot of information there with more detail. “An Enemy of the People,” written in 1882, could almost be the story of CoViD and Dr. Fauci.

Robert Reich makes the case for what he calls “Nauseous Optimism,” by which he means being optimistic even when one’s stomach is churning. but he explains it better than I can.

One of the Mar-a-Lago documents case who has been known as “Employee Number 5” is speaking out on the case and his part in it. I think he’s hoping it will make a bigger difference than I think it will – but any difference in the right direction is a good thing.

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Mar 022024
 

I learned that another state – Illinois – is now onn the bandwagon of keeping Trump off the ballot. Good luck to all of us.

Heather Cox Richardson is reminded in our time of the times of the “Know Nothing” Party in the 1850s. And with good reason. The actual party name was “the Native American Party,” and later just “the American Party.”  Just as misidentified as today’s “Patriots.”

(I have multiple sources for all of this – Wikipedia is the main one but Performance Today deserves mention.) Today being the second day of Women’s History month, and on the heels of Black History month, it seems to me a good day to bring up Florence Beatrice Price, an American woman of color who was a composer in the 20th Century. She was told many times she was “not a good fit” by publishers – but the Chicago Symphony played her works and they were met with appreciation. Wanamaker’s there (the first retail department store in the U.S.) would hold annual composition contests for local composers, and she was a consistent winner, in one year winning first, second, and third place. But all her manuscripts were kept in the home she used as a summer residence, and when she died, it was abandoned. It was not until 2009 that someone interested in purchasing the home discovered them, and fortunately, was musical enough to know what they had. The works included four symphonies, two violin concertos, a piano concerto, other orchestral works, songs, choral works, chamber music, arangements of spirituals, and probably more piano solos than anything else. According to Performance Today, she is not the most performed female composer in America. And that happened in the 15 years between 2009 and now. I am so glad that I have lived to hear at least some of it. I am listening to one on the radio as I type – her Symphony #3. And it is beautiful.

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Jan 102024
 

Yesterday I got a bunch of stuff done – mostly on the computer rather than with physical objects, but it still tired me. I guess whie I was busy, the Appeals Court looked at TFG’s “immunity” claim and apparantly those looks were all askance.

I thought this was kind of nice. I well remember Andy Kim starting on cleanup on that day.

The Theater of War has a new project called “An Enemy of the People,” using the play by Ibsen. “The play tells the story of a doctor who discovers the water supply in his small, rural town has been poisoned by a tannery. Despite his efforts to convey the truth to the public, the doctor fails to save his community from environmental disaster and is ultimately scapegoated for his whistleblowing.” Ibsen didn’t pussyfoot around the truth, as long ago as 1882. This sounds a lot like how Fauci was treated – and in fact Dr. Fauci will be one of the actors (the actors will change from one event to another so if you want to hear what he has to say you will need to checking cast lists.) The first two events are 2/22 and 2/24, and Fauci is scheduled in the 2/24 event but not the 2/22 event. This is the link for 2/24 (it looks like you might be able to scroll from it.)

Here’s my response to the “poop Nazi” telling everyone to get over stuff – stuff like their kids being shot in school:

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Sep 022023
 

Yesterday, Mary Trump (Mary L. Trump, to distinguish her from her grandmother) wrote about the Supreme Court, in an essay on Substack she calls “The Lowest Court, Part 2.” She remarks, not just on the ethics issues, but on the contempt shown by the court for the people, which really is reminiscent of France before the Revolution. If you were to tell me that Alito, or Kavanaugh, or even Roberts had said “Let them eat cake,” I’d probably believe it. If you want to look deeper, here’s the link – just remember to look for the “continue reading” and click it.

Cartoon –

Short Takes –

HuffPost – Biden Administration Reveals First 10 Drugs For Medicare Price Negotiation
Quote – All told, the 10 drugs on the list accounted for $50.5 billion in total spending in Medicare’s outpatient prescription drug program for the period between June 1, 2022, and May 31, 2023, according to the Department of Health and Human Services. That’s about one-fifth of what the program, known as Part D, spent on all prescription drugs during that period. The announcement represents the first step in a process set to unfold over the coming year, with the government collecting data and public input, and then exchanging price offers with manufacturers over how much Medicare will pay for the named drugs.
Click through for details. Not surprisingly, the article bears the subtitle “It’s the first step in a process that will mean lower prices in 2026 ― unless the drug industry and its allies find a way to block it.”

The Daiy Beast – How One Citizen Fought Back Against a Cop’s Road Rage
Quote – While driving home in his Ford Mustang, [New Mexico motorist Mario Rosales] legally passed a pickup truck, and the other driver started tailgating him. Road rage can be deadly, so Rosales grew concerned. No matter which way he went, the truck stayed in his rearview mirror. Rosales eventually reached his home in Roswell, New Mexico, hoping the truck would keep going. Instead, the vehicle blocked Rosales in his driveway, and the stranger behind the wheel started yelling and cursing at him. At this point Rosales was not just concerned. He was scared for himself and his family members in the house.
Click through for the story, which has a happy ending – this time – finally. Too many do not.

Food For Thought

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