Jul 012024
 

Yesterday was quite a day.When I got into the car to go see Virgil, of course it started right up, but when I backed up and started to turn, the power steering was clearly dead. I decided not to call USAA, even though that’s already paid for through my insurance, because they are kind of a one-trick pony – if it doesn’t fit into the most common categories, they’ll only tow it. And if it turned out to be just brake fluid, I wanted to be able to see Virgil. Instead I called the guy who (you may or may not remember) I called on our anniversary who successfully jumped it, noticed there was a spill under my front end ad topped up the radiator, and noticed my tires were low and inflated them all. Well, it wasn’t the fluid, and it wasn’t any of the fuses,so he went under the car, and it turned out it was simple after all. I learned that under the car there are spindles around which the belts get rotated which send electric power to whatever needs it. there are more than one (I think he said three) and there are at least two belts on any one of them. It turns out the steering is on the same one as the air conditioner. The steering belt was in place, but the air conditioner one had gotten knocked off (which can happen if one hits a pothole or a bump) and without both belts, the spindle wasn’t turning right. He put the A/C belt back in place and that fixed the steering belt and therefore the steering. Trying to explain it to Virgil, I just said “Dude’s a wizard,” but actually he’s just a mechanic who is trained all around and therefore has a lot more know-how than the guys who just jump or change tires or bring gas or tow cars. And, yes, he charges, but he also gives veterans a discount. So I got there, almost 2 hours later than I had planned, but I was and am so happy to have gotten there. We weren’t able to play as much cribbage as usual but we did play some. The hands ranhed from dire through mediocre up to halfway decent. But we enjoyed it. Also – las night – my local radio station devoted is pretty new Broadway show to “1776”   For me that’s a hanky alert in a good way

On Friday, Marian Wright Edelmann posted a piece on the Sandy Hook survivors now graduating from high school. It’s a hanky alert. and I held it over the weekend to try to stay upbeat. But it deserves a read.

It’s anybody’s guess what SCROTUS is going to do with this when it gets there – and, in some form, it will. Personlly, I think if they ere truly the originalists they claim to be, they would decide, Sure, anyone can have a gun, aslong as it was made prior to 1800, or a replica of a gun made prior to 1800 with no updates. (‘m inclined to doubt whther any of the RW gun nuts can even load a musket.

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Jun 152024
 

Yesterday, the Daily Beast had an article titled “Who Will Live Longer—Trump or Biden?” My immedaite response was “your answer to that depends on whether you believe in science, or in the folk belief that evil lives longer.” And then I thought, no, it won’t really. Because the same people who believe folktales are true are the ones who think TFG is good.” So, either eay, the answer is Biden. And Robert Reich’s DEBUNK Episode 3 was published.

Tina Peters is not what I would like to see from Colorado in national news. Not that this story is directly about her, but it’s about what Mesa County is doing to attempt to move on from her, and her name is the one that leaps out.

For Pride Month, here’s an article about the life (and death at 86) of a transgender woman to whom we all owe gratitude if we ever use anything involving microchips. I don’t ecpect her legacy to impress any gender bigots, of course, but I also don’t expecct any of them to be reading this.

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Apr 062024
 

When I saw this article (and particularly when I learned something else I’ll get to after the article). I figured I had to go right to the top – Athena, the goddess of wisdom. Athena is likely so intellectual because she wasn’t born as we understand it – she emerged fully formed and an adult from Zeus’s head (I assume without the helmet, although the size of the helmet does suggest a large brain.)

At a time when we are aware that Alzheimer’s disease exists, and that there is no cure, many of us are terrified of it – of having it ourselves, and of it happening to someone near and dear. I know my mother was terrified of it. (She was spared it – she was still expertly solving crossword puzzles until her final coma, caused by pneumonia, at age 93.) So I can’t imagine anyone willing to miss out on any opportunity to avoid it, or to slow its progress.
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New studies suggest millions with mild cognitive impairment go undiagnosed, often until it’s too late

Mild cognitive impairment can be an early sign of Alzheimer’s disease or other dementias.
ivanastar/iStock via Getty Images Plus

Soeren Mattke, University of Southern California and Ying Liu, USC Dornsife College of Letters, Arts and Sciences

Mild cognitive impairment – an early stage of dementia – is widely underdiagnosed in people 65 and older. That is the key takeaway of two recent studies from our team.

In the first study, we used Medicare data for about 40 million beneficiaries age 65 and older from 2015 to 2019 to estimate the prevalence of mild cognitive impairment in that population and to identify what proportion of them had actually been diagnosed.

Our finding was sobering: A mere 8% of the number of cases with mild cognitive impairment that we expected based on a statistical model had actually been diagnosed. Scaled up to the general population 65 and older, this means that approximately 7.4 million cases across the country remain undiagnosed.

In the second study, we analyzed data for 226,756 primary care clinicians and found that over 99% of them underdiagnosed mild cognitive impairment in this population.

Why it matters

Mild cognitive impairment is an early symptom of Alzheimer’s disease in about half of cases and progresses to dementia at a rate of 10% to 15% per year. It includes symptoms such as losing the ability to remember recent events and appointments, make sound decisions and master complex tasks. Failure to detect it might deprive patients of an opportunity to get treated and to slow down disease progression.

Mild cognitive impairment can sometimes be caused by easily addressable factors, such as medication side effects, thyroid dysfunction or vitamin B12 deficiency. Since mild cognitive impairment has the same risk factors as cardiovascular disease, such as high blood pressure and cholesterol, medication management of these risks combined with diet and exercise can reduce the risk of progression.

In 2023, the Food and Drug Administration approved the drug lecanemab as the first disease-modifying treatment for Alzheimer’s disease, the most common cause of mild cognitive impairment. In contrast to previous drugs, which can temporarily improve symptoms of the disease, such as memory loss and agitation, this new treatment addresses the underlying cause of the disease.

Lecanemab, a monoclonal antibody, reduces amyloid plaques in the brain, which are toxic protein clumps that are believed to contribute to the progression of the disease. In a large clinical trial, lecanemab was able to reduce the progression of early-stage Alzheimer’s disease. A similar drug, donanemab, also succeeded in a clinical trial and is expected to be approved sometime in 2024.

However, these drugs must be used in the early stages of Alzheimer’s disease, ideally when a patient has only mild cognitive impairment, as there is no evidence that they are effective in advanced stages.

An earlier diagnosis leads to early treatment and better outcomes.

What still isn’t known

Many factors contribute to the lack of timely detection. But researchers don’t have a good understanding of the relative importance of those individual factors or how to reduce the high rate of underdiagnosis.

While distinct, symptoms are subtle and their slow progression means that they can be overlooked or misinterpreted as normal aging. A neurologist in China told our research team that diagnosis rates spike in China after the New Year’s holiday, when children who haven’t seen their parents for a year notice changes that are harder to pick up when interacting with someone daily.

Doctors also commonly discount memory concerns as normal aging and doubt that much can be done about it. While cognitive tests to distinguish mild cognitive impairment from pathologic decline do exist, they take about 15 minutes, which can be hard to come by during the limited time of a doctor’s visit and may require a follow-up appointment.

What’s next

People, particularly those in their 60s and beyond, as well as their families and friends need to be vigilant about cognitive decline, bring it up during doctor’s appointments and insist on a formal assessment.

The Medicare yearly “wellness” visit is an opportunity to explore such concerns, but only about half of beneficiaries take advantage of it.

Just as physicians ask patients about unexplained weight loss and take those concerns seriously, we believe questions that explore a patient’s cognitive state need to become the norm.

The Research Brief is a short take on interesting academic work.The Conversation

Soeren Mattke, Director of the USC Dornsife Brain Health Observatory, University of Southern California and Ying Liu, Research Scientist, Center for Economic and Social Research, USC Dornsife College of Letters, Arts and Sciences

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Pat B, (who is celebrating her fiftieth wedding anniversary today) has graciously given me permission to share that this coming Friday she has an appointment with her Doctor to discuss her memory loss. While no one can prove it, I would not be surprised to learn this was inspired by Athena. I can’t imagine anything wiser than getting checked out for any possible signs of dementia, knowing that waiting will not make it any better but it could make it worse. Thank you, Athena, and may you inspire all of us who are 65 or older to be wise also.

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